Enantioselective synthesis of antifolates

Details Enantioselective synthesis of antifolates Enantioselective synthesis of antifolates

1995-05-22

1997-05-27

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40102

Patent

active

056333730

ABSTRACT:
A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

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G. M. Ramos Tombo, Tetrahedron Letters, vol. 27, No. 47, pp. 5707-5710, 1986.
G. M. Ramos Tombo, vol. 29, pp. 43-50, Studies of Organic Chemistry, Elsevier, Amsterdam, 1987.
Yi-Fong Wang and Charles J. Sih, Tetrahedron Letters, vol. 25, No. 44, pp. 4999-5002, 1984.
V Kerscher and W. Kreiser, Tetrahedron Letters, vo. 28, No. 5, pp. 531-534, 1987.
Zbigniew J. Kaminski, Tetrahedron Letters, vo. 26, No. 24, pp. 2901-2904, 1985.

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