Enantioselective synthesis of antifolates

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544279, 552 10, 552 11, 552 12, 558398, 558406, 560105, 560250, 560254, 560231, 560234, 560232, 546243, 546287, 546288, 546298, C07D47104, A61K 31505

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active

055167764

ABSTRACT:
A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

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G. M. Ramos Tombo, Tetrahedron Letters, vol. 27, No. 47, pp. 5707-5710, 1986.
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Yi-Fong Wang and Charles J. Sih, Tetrahedron Letters, vol. 25, No. 44, pp. 4999-5002, 1984.
V Kerscher and W. Kreiser, Tetrahedron Letters, vo. 28, No. 5, pp. 531-534, 1987.
Zbigniew J. Kaminski, Tetrahedron Letters, vo. 26, No. 24, pp. 2901-2904, 1985.

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