Enantioselective production of chiral carboxylic acids

Details Enantioselective production of chiral carboxylic acids Enantioselective production of chiral carboxylic acids

1992-10-26

1993-12-28

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435189, 435280, C12P 740, C12N 902

Patent

active

052738957

ABSTRACT:
A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carboxylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is particularly useful for producing NSAIDs of the profen class from readily available precursors. Preferred microorganisms are Gram-negative rod bacteria.

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