Enantioselective oxazaborolidine catalysts

Details Enantioselective oxazaborolidine catalysts Enantioselective oxazaborolidine catalysts

1995-10-10

1999-12-21

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Borate esters

546339, 549401, 548110, 564 10, 564355, 568 1, 568808, 568814, 568878, C07F 504, C07C 2704

Patent

active

060051337

ABSTRACT:
The enantioselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the presence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulae (I) and (II). The compounds of formulae (I) and (II) may be isolated and purified prior to use in the reduction reactions or the compounds of formulae (I) and (II) may be generated in situ.

REFERENCES:
patent: 3137723 (1964-06-01), Pribyl et al.
patent: 4749809 (1988-06-01), Yoneyoshi
patent: 4923999 (1990-05-01), Yoneyoshi
patent: 4943635 (1990-07-01), Corey
Itsuno et al., Journal of the Chemical Society, Chemical Communications, 1983, 469-70.
Martens et al., Tetrahedron: Asymmmetry, 3, 347-50 (1992).
Matsunaga et al., Tetrahedron Letters, 32, 7715-18 (1991).
Tanaka et al., Journal of the Chemical Society, Chemical Communications, 1991, 1311-12.
Reetz et al., Angew. Chemie., Int. Ed. Eng. 26, 1141-3 (1987).
Didier et al., Tetrahedron, 47, 4941-58 (1991).
Brown et al., Tetrahedron: Asymmetry, 1, 869-72 (1990).
Brown et al., Tetrahedron: Asymmetry, 3 261-66 (1992).
Corey et al., Tetrahedron Letters, 30, 5547-50 (1989).
Corey et al., Tetrahedron Letters, 30, 6257-78 (1989).
Cho et al., Tetrahedron: Asymmetry, 3, 1539-42 (1992).
Brooks et al., Organic Mass Spectrometry, 2, 1023-32 (1969).
Brown et al., Accounts of Chemical Research, 25, 16-24 (1992).
Cho et al., Tetrahedron: Asymmetry, 3, 1583-90 (1992).
Brooks, et al., Chemical Abstracts, 72, 26317v (1970).
Mskinley et al., Chemical Abstracts, 80, 96307f (1980).
Berenguer et. al., Tetrahedron Asymmetr, vol. 4, No. 1, pp. 13-16, Jan. 1993.

Affiliated with

Also associated with

Rating

Enantioselective oxazaborolidine catalysts does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enantioselective oxazaborolidine catalysts, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enantioselective oxazaborolidine catalysts will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-506797