Enantioselective hydrolysis of ketoprofen esters by beauveria ba

Details Enantioselective hydrolysis of ketoprofen esters by beauveria ba Enantioselective hydrolysis of ketoprofen esters by beauveria ba

1993-03-09

1995-10-10

Rollins, John W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435911, 435171, C12P 4100

Patent

active

054570514

ABSTRACT:
A process for producing substantially pure R-ketoprofen by the enantioselective hydrolysis of racemic ketoprofen choline ester is disclosed. The process utilizes either intact Beauveria bassiana hyphae or an R-specific ester hydrolase isolated therefrom. The ester hydrolase has an approximate molecular weight of 17,800 daltons and an N-terminal sequence of Ala-Pro-Asp-W-Ile-Ile-Gln-Gly-Leu-Ser-Arg-Ala-X-Asp-Gly-Gln-Asp.

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