Enantioselective hydrogenation of intermediates in the...

Details Enantioselective hydrogenation of intermediates in the... Enantioselective hydrogenation of intermediates in the...

2006-02-21

2006-02-21

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S292000

Reexamination Certificate

active

07002017

ABSTRACT:
The invention relates to a process for preparing the compounds of general formula Iby enantioselective hydrogenation of the compounds of formula IIin the presence of special hydrogenation catalysts. The invention is characterised by high enantioselectivity, providing easy access to a category of important pharmaceutical compositions, i.e. intermediates for the synthesis of tipranavir.

REFERENCES:
patent: WO 99/12919 (1999-03-01), None
patent: WO 00/55150 (2000-09-01), None
Jens Holz et al; Synthesis of a New Chiral Bisphospholane Ligand for the Rh(I)-Catalyzed Enantioselective Hydrogenation of Isomeric beta-Acylamido Acrylates; J. Org. Chem 2003 vol. 68 pp. 1701-1707; American Chemical Society.
Steve R. Turner et al; Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class; J. Med. Chem 1998 vol. 41 pp. 3467-3476; American Chemical Society.
Copy of International Search Report Reference No. PCT/EP2004/002894.

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