Enantioselective epoxide hydlrolase and method for preparing...

Details Enantioselective epoxide hydlrolase and method for preparing... Enantioselective epoxide hydlrolase and method for preparing...

2006-10-04

2011-10-04

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S123000

Reexamination Certificate

active

08030048

ABSTRACT:
The present invention relates to enantioselective epoxide hydrolase proteins isolated from marine microorganisms, which has high enantioselectivity to various epoxide substrates, and a method of preparing the epoxides with high enantio-purity by using the epoxide hydrolases. The enantioselective hydrolase protein of the present invention can be applied for the preparation of enantiopure epoxides with high bioactivity at a high yield.

REFERENCES:
Morisseau C. et al., Purification and characterization of a hightly enantioselective epoxide hydrolase fromAspergillus niger, in Eur J. Biochem, 1999, vol, 263 (2), pp. 386-395 See the abstract and Figs 1-3.
Rink R. at al. Primary structure and catalytic mechanism of the epoxide hydrolase fromAgrobacterium radiobacterAD1, in J. Bio.. Chem., 1997, vol. 272(23), pp. 14650-14657 See the abstract, Figs 2-3 and Table 1.
NCBI GenBank Accession No. YP—457985 Hypothetical Protein ELI-05480 [Erythrobacter litoralisHICC2594] Mar. 30, 2006.
NCBI GenBank Accession No. YP—458376 Probably epoxide Hydrolase [Erythrobacter litoralisHTCC2594] Mar. 30, 2006.
NCBI GenBank Accession No. ABC63553 Possible Epoxide Hydrolase-related Protein [Erythrobacter litoralisHTCC2594] Jan. 27, 2006.
NCBI GenBank Accession No. YP-615140 Epoxide Hydrolase-like Protein [Sphingopyxis alaskensisRB2256] May 30, 2006.
NCBI GenBank Accession No. YP-497537 Epoxide Hydrolase-like [Novoshingobium aromaticivoransDSM 12444] Mar. 30, 2006.
NCBI GenBank Accession No. ZP-0104743 Putative Epoxide Hydrolase [Rodobacterales bacterium HTCC2654] Jan. 10, 2006.
International Search Report and Written Opinion PCT/KR2006/004003 dated Dec. 22, 2006.

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