Enantiomers of .beta.-[(2-amino-1-naphthalenyl) thiol]-.alpha.-h

Details Enantiomers of .beta.-[(2-amino-1-naphthalenyl) thiol]-.alpha.-h Enantiomers of .beta.-[(2-amino-1-naphthalenyl) thiol]-.alpha.-h

1989-06-29

1991-02-26

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 10, 562427, C07B 5700, C07C32330

Patent

active

049963520

ABSTRACT:
A process for preparing optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones comprising resolution of rac-.beta.-[(2-amino-1-naphthalenyl)thio]-.alpha.- hydroxy-4-methoxybenzenepropanoic acid and converting the optically active acids so obtained into final products is described. The end product naphtho[1,2-b][1,4]thiazepin- 4(5H)-ones have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure, and as agents for treating ischemia.

REFERENCES:
patent: 4652561 (1987-03-01), Mohacsi et al.
Helvetica Chimica Acta, vol. 39, Fasciculus II, (1956), No. 49, pp. 429-440.
DE 3337-176A (Abstract), Apr. 19, 1984.
J61069756A (Abstract), Apr. 1, 1986.
ES8500250A (Abstract), Jan. 1, 1985.
60-243062 (Japanese Abstract), Dec. 3, 1985.
59-144750 (Japanese Abstract), Aug. 18, 1984.
59-144751, (Japanese Abstract), Aug. 18, 1984.
59-110668, (Japanese Abstract), Jun. 26, 1984.

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