Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]m

Details Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]m Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]m

1998-07-21

2000-01-11

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558419, A61K 31275, C07C25530

Patent

active

060136685

ABSTRACT:
The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.

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patent: 5578599 (1996-11-01), Diani et al.
Meisheri, K.D. et al, "Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil", Biochemical Pharmacology, vol. 45, No. 2 pp. 271-279, 1993.
Buhl, A.E. et al, "Potassium Channel Conductance: A Mechanism Affecting Hair Growth both In Vitgro and In Vivo", J. Invest. Dermatol., vol. 98, No. 3, pp. 315-319, Mar. 1992.
Pettinger, W.A. et al, "Side Efects of Vasodilator Therapy", Suppl. II Hypertension, vol. 11, No. 3, pp. II-34-II-36, Mar. 1998.

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