Enantiomerically pure opioid diarylmethylpiperazine as a...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S379000

Reexamination Certificate

active

11187755

ABSTRACT:
(−)3-((S)-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)(3-thienyl)methyl)phenol and pharmaceutically acceptable esters or salts thereof, in essentially enantiomerically pure form have utility as a cardioprotection agent.

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patent: WO 93/15062 (1993-08-01), None
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Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; Xu, Heng; Smith, Larren E.; Blisky, Edward J.; Davis, Peg; Rice, Kenner C.; Journal of Medicinal Chemistry, 37(14), 2125-8 (English) 1994.
Corbett, A. et al., “Opioid Receptors”, [online] no date. [retrieved on May 27, 2004]. Retrieved from the internet, http://opioids.com/receptors/.
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Knapp, Richard J.; Santoro, Giovanna; De Leon, Irene A.; Lee, Katharine B.; Edsall, Sidney A.; Waite, Sue; Malatynska, Ewa; Varga, Eva; Calderon, Silvia N.; et al. Journal of Pharmacology and Experimental Therapeutics, 277(3), 1284-1291 (English) 1996.

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