Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-01
1998-04-14
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514866, A61K 3152
Patent
active
057391386
ABSTRACT:
There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
REFERENCES:
patent: 3422107 (1969-01-01), Mohler et al.
patent: 4515795 (1985-05-01), Hinze et al.
patent: 4525309 (1985-06-01), Matteson et al.
patent: 4576947 (1986-03-01), Hinze et al.
patent: 4636507 (1987-01-01), Kreutzer et al.
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5096906 (1992-03-01), Mandell et al.
patent: 5112827 (1992-05-01), Saunders et al.
patent: 5118500 (1992-06-01), Hanel et al.
patent: 5272153 (1993-12-01), Mandell et al.
patent: 5310666 (1994-05-01), Aretz et al.
patent: 5409935 (1995-04-01), Schubert et al.
Bianco et al., Blood, vol. 78, No. 5, pp. 1205-1211, "Phase I-II Trial of Pentoxifylline for the Prevention of Transplant-Related Toxicities Following Bone Marrow Transplantation", 1991.
Davis et al., Applied And Environmental Microbiology, vol. 48, No. 2, pp. 327-331, "Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxidation of Pentoxifylline", 1984.
Davis et al., Xenobiotica, vol. 15, No. 12, pp. 1001-1010, "Microbial Models of Mammalian Metabolism: Stereospecificity of Ketone Reduction with Pentoxifylline", 1985.
Matteson et al., J. Am. Chem. Soc., vol. 108, pp. 810-819, "99% Chirally Selective Syntheses via Pinanediol Boronic Esters: Insect Pheromones, Diols, and an Amino Alcohol", 1986.
Soundarajan et al., J. Org. Chem., vol. 55, pp. 2274-2275, "Hydroboration with Boron Halides and Trialkylsilanes", 1990.
Bianco James A.
Porubek David
Singer Jack
Woodson Paul
Cell Therapeutics Inc.
Criares Theodore J.
Faciszewski Stephen
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