Enantiomerically pure aminoheteroaryl compounds as protein...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S253120, C514S341000, C514S349000, C544S360000, C546S275400, C546S297000, C546S194000

Reexamination Certificate

active

07858643

ABSTRACT:
Enantiomerically pure compound of formula 1are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

REFERENCES:
patent: 5587458 (1996-12-01), King et al.
patent: 5747498 (1998-05-01), Schnur et al.
patent: 5792783 (1998-08-01), Tang et al.
patent: 5834504 (1998-11-01), Tang et al.
patent: 5861510 (1999-01-01), Piscopio et al.
patent: 5863949 (1999-01-01), Robinson et al.
patent: 5877305 (1999-03-01), Huston et al.
patent: 5883113 (1999-03-01), Tang et al.
patent: 5886020 (1999-03-01), Tang et al.
patent: 6071935 (2000-06-01), Lyssikatos
patent: 6080769 (2000-06-01), Lyssikatos et al.
patent: 6106864 (2000-08-01), Dolan et al.
patent: 6150377 (2000-11-01), Lyssikatos et al.
patent: 6194438 (2001-02-01), Yang et al.
patent: 6258824 (2001-07-01), Yang
patent: 6284764 (2001-09-01), Kath et al.
patent: 6465449 (2002-10-01), Kath et al.
patent: 6479513 (2002-11-01), Yang
patent: 6495564 (2002-12-01), Lyssikatos et al.
patent: 6586447 (2003-07-01), Lyssikatos et al.
patent: 6596735 (2003-07-01), Yang
patent: 6682736 (2004-01-01), Hanson et al.
patent: 7230098 (2007-06-01), Cui et al.
patent: 7465842 (2008-12-01), Kung et al.
patent: 7585853 (2009-09-01), Berg et al.
patent: 2003/0166675 (2003-09-01), Yang
patent: 2004/0186113 (2004-09-01), Berg et al.
patent: 2005/0009840 (2005-01-01), Cui et al.
patent: 2005/0227997 (2005-10-01), Noe et al.
patent: 2006/0052396 (2006-03-01), Berg et al.
patent: 2006/0063782 (2006-03-01), Murray et al.
patent: 2006/0128724 (2006-06-01), Cui et al.
patent: 2006/0178374 (2006-08-01), Cui et al.
patent: 2007/0072874 (2007-03-01), Cui et al.
patent: 2008/0293769 (2008-11-01), Cui et al.
patent: 606046 (1994-07-01), None
patent: 780386 (1997-06-01), None
patent: 0 818 442 (1997-07-01), None
patent: 0 952 148 (1999-03-01), None
patent: 1 084 114 (1999-05-01), None
patent: 931788 (1999-07-01), None
patent: 1 004 578 (1999-10-01), None
patent: 9912961.1 (1999-08-01), None
patent: WO 90/05719 (1990-05-01), None
patent: WO 91/11172 (1991-08-01), None
patent: WO 94/02518 (1994-02-01), None
patent: WO 95/19970 (1995-07-01), None
patent: WO 95/21613 (1995-08-01), None
patent: WO 96/27583 (1996-09-01), None
patent: WO 96/33172 (1996-10-01), None
patent: WO 97/13760 (1997-04-01), None
patent: WO 97/22596 (1997-06-01), None
patent: WO 97/32856 (1997-09-01), None
patent: WO 98/02424 (1998-01-01), None
patent: WO 98/02434 (1998-01-01), None
patent: WO 98/02437 (1998-01-01), None
patent: WO 98/02438 (1998-01-01), None
patent: WO 98/03516 (1998-01-01), None
patent: WO 98/07697 (1998-02-01), None
patent: WO 98/14451 (1998-04-01), None
patent: PCT/IB98/01113 (1998-07-01), None
patent: WO 98/30566 (1998-07-01), None
patent: WO 98/33768 (1998-08-01), None
patent: WO 98/34915 (1998-08-01), None
patent: WO 98/34918 (1998-08-01), None
patent: WO 98/50356 (1998-11-01), None
patent: WO 98/54093 (1998-12-01), None
patent: WO 98/55148 (1998-12-01), None
patent: WO 99/10349 (1999-03-01), None
patent: WO 99/16755 (1999-04-01), None
patent: WO 99/24440 (1999-05-01), None
patent: WO 99/29667 (1999-06-01), None
patent: WO 99/35132 (1999-07-01), None
patent: WO 99/35146 (1999-07-01), None
patent: WO 99/52889 (1999-10-01), None
patent: WO 99/52910 (1999-10-01), None
patent: WO 99/61422 (1999-12-01), None
patent: WO 00/35298 (2000-06-01), None
patent: WO 00/37107 (2000-06-01), None
patent: WO 00/38665 (2000-07-01), None
patent: WO 00/38715 (2000-07-01), None
patent: WO 00/38716 (2000-07-01), None
patent: WO 00/38717 (2000-07-01), None
patent: WO 00/38718 (2000-07-01), None
patent: WO 00/38719 (2000-07-01), None
patent: WO 00/38730 (2000-07-01), None
patent: WO 00/38786 (2000-07-01), None
patent: WO 03/004472 (2003-01-01), None
patent: WO 03/004475 (2003-01-01), None
patent: WO 2004/004720 (2004-01-01), None
patent: WO 2004/055005 (2004-07-01), None
patent: WO2004/076412 (2004-09-01), None
patent: WO 2005/002673 (2005-01-01), None
patent: WO2006/021886 (2006-03-01), None
U.S. Appl. No. 60/168,217 Equiv to WO 01/40217, Nov. 30, 1999, Pfizer Products Inc.
Finnin, B., et al., “Transdermal Penetration Enhancers: Applications, Limitations, and Potential,”Journal of Pharmaceutical Sciences, 1999, 955-958, vol. 88, No. 10.
Haleblian, J., et al., “Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications,”Journal of Pharmaceutical Sciences, 1975, 1269-1288, vol. 64, No. 8.
Jiang, W., et al., “Hypatocyte Growth Factor/Scatter Factor, Its Molecular, Cellular and Clinical Implications in Cancer,”Critical Revues in Oncology Hematology, 1999, 209-248, vol. 29.
Ma, P., et al., “c-MET: Structure, Functions and Potential for Therapeutic Inhibition,”Cancer Metastasis Reviews, 2003, 309-325, vol. 22.
Ma, P., et al., “c-METMutational Analysis in Small Cell Lung Cancer: Juxtamembrane Domain Mutations Regulating Cytoskeletal Functions,”Cancer Research, 2003, 6272-6281, vol. 63.
Maulik, G., et al., “Role of the Hepatocyte Growth Factor Receptor,c-MET, in Oncogenesis and Potential for Therapeutic Inhibition,”Cytokine&Growth Factor Reviews, 2002, 41-59, vol. 13.
Technikova-Dobrova, Z., et al., “Spectrophotometric Determination of Functional Characteristics of Protein Kinases With Coupled Enzymatic Assay,” 1991, FEBS Lett., 69-72, vol. 292, No. 1,2.
Verma, R., et al., “Current Status of Drug Delivery Technologies and Future Directions,”Pharmaceutical Technology On-line, 2001, 1-14, vol. 25, No. 2.
Voller, et al., “Enzyme-Linked Immunosorbent Assay,”Manual of Clinical Immunology 2 Edition, 359-371, Rose And Friedman, Am. Soc. of Microbiology, Washington, D. C., 1980.
Sawyer, T., “Cancer Metastatis Therapeutic Targets and Drug Discovery: Emerging Small-Molecule Protein Kinase Inhibitors,”Expert Opinion on Investigational Drugs, 2004, 1-19, vol. 13, No. 1.

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