Enantiomerically enriched .alpha.,.alpha.-distributed amino acid

Details Enantiomerically enriched .alpha.,.alpha.-distributed amino acid Enantiomerically enriched .alpha.,.alpha.-distributed amino acid

1997-04-11

2000-10-10

Seaman, D. Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548228, 548229, C07D26304, C07D26318, C07D26342

Patent

active

061303372

ABSTRACT:
Compositions and methods for the preparation of enantiomerically enriched .alpha.,.alpha.-disubstituted amino acid precursors are presented. Briefly, allylic electrophiles are alkylated with oxazolones in the presence of a base and catalytic quantities of a transition metal complex incorporating a chiral phosphine ligand to yield 4,4-disubstituted-5(4H)-oxazolones. These precursors may be subsequently transformed either synthetically or enzymatically to yield enantiomerically enriched .alpha.,.alpha.-disubstituted amino acids.

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