Enantiomeric resolution of aryl-substituted aliphatic carboxylic

Details Enantiomeric resolution of aryl-substituted aliphatic carboxylic Enantiomeric resolution of aryl-substituted aliphatic carboxylic

1992-10-14

1994-01-11

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

558406, 560 56, 560 57, 560 60, 560 78, 560100, 560101, 560105, C07B 5700

Patent

active

052783375

ABSTRACT:
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties:

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Collet et al., Chem. Rev. 80(3), pp. 215-230, (1980).
Jaques et al., Enantiomers, Racemates and Resolutions, J. Wiley & Sons, New York, New York, (1981) pp. 167-213.
Collet, A., pp. 91-110 in Problems and Wonders of Chiral Molecules, Simonyi, M. (Ed.), Akademiai Keado, Budapest, (1990).

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