Enantiomeric resolution

Details Enantiomeric resolution Enantiomeric resolution

1992-10-14

1993-09-28

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

556114, 556131, 558414, 560 21, 560 23, 560 38, 560 39, 560 43, 560 44, 560 56, 560 59, 560 60, 560 61, 560 62, 560100, 560103, C07B 5700

Patent

active

052488136

ABSTRACT:
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties:

REFERENCES:
patent: 4831147 (1989-05-01), Russell
patent: 4865770 (1989-09-01), Piselli
patent: 4931587 (1990-06-01), Piselli
patent: 4973745 (1990-11-01), Blaschke et al.
Collet et al., Chem. Rev. 80(3), pp. 215-230 (1980).
Jaques et al., Enantiomers, Racemates and Resolutions, Chapter 3, J. Wiley & Sons, New York, N.Y., (1981) pp. 167-213.
Collet, A., pp. 91-110 Problems and Wonders of Chiral Molecules, Simonyi, M. (Ed.), Akademai Keado, Budapest (1990).

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