Enantiomeric resolution

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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558414, 560 56, 560 57, 560 60, 560100, 560101, 560105, C07B 5700

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active

052604829

ABSTRACT:
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process combines an aryl substituted aliphatic carboxylic acid, a base and water in an inert solvent to make a hydrated salt of the said acid. The process leads to enhanced yield of an enantiomerically enriched hydrated salt of the carboxylic acid.

REFERENCES:
patent: 4831147 (1989-05-01), Russell
patent: 4865770 (1989-09-01), Piselli
patent: 4910309 (1990-03-01), Kershner et al.
patent: 4931587 (1990-06-01), Piselli
patent: 4973745 (1990-11-01), Blaschke et al.
Collet et al., Chem. Rev. 80(3), pp. 215-230 (1980).
Jaques et al., Enantiomers, Racemates and Resolutions, Chapter 3, J. Wiley & Sons, New York, N.Y., (1981), pp. 167-213.
Collet, A., pp. 91-110, Problems and Wonders of Chiral Molecules, Simonyi, M. (Ed.), Akademiai Keado, Budapest (1990).

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