Enantiomeric enrichment of (R,S)-3-quinuclidinol

Details Enantiomeric enrichment of (R,S)-3-quinuclidinol Enantiomeric enrichment of (R,S)-3-quinuclidinol

1992-06-19

1993-06-01

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435836, 435839, C12P 1712

Patent

active

052159183

ABSTRACT:
A method for the enantiomeric enrichment of 3-quinuclidinol is disclosed, comprising acid anhydride esterification of the alcohol, followed by preferential enzymatic hydrolysis with a subtilisin protease.

REFERENCES:
Rehavi, M., Life Sci. 21(9):1293-1302 (1977).
Ringdahl, B., Acta Pharm. Suec. 16(4):281-3 (1979).

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