Enantiomeric enrichment and stereoselective synthesis of chiral

Details Enantiomeric enrichment and stereoselective synthesis of chiral Enantiomeric enrichment and stereoselective synthesis of chiral

1990-07-09

1992-12-08

Elmore, Carolyn

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435106, 435128, C12P 1300

Patent

active

051697807

ABSTRACT:
Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

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