Enantiomer (-) of tenatoprazole and the therapeutic use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S118000

Reexamination Certificate

active

07034038

ABSTRACT:
The invention relates to enantiomer (−) of tentoprazole. The inventive enantiomer (−) of tenatoprazole, or (−)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]imidazol[4,5-b]pyridine exhibits improved pharmacokinetic properties which make it possible to use a once a day posology of a drug for relevant indications. Said invention can be used for curing digestive pathologies.

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Kakinoki, abstract only, CA 131:208915, abstract of Methods and Findings in Experimental and Clinical Pharmacology, VOl 21(3), pp 179-187, 1999.
Uchiyama, abstract only, CA 131:139269, Methods and Findings in Experimental and Clinical Pharmacology, VOl 21(2). pp 115-122, 1999.
Uchiyama, abstract only, CA 131:125259, abstract of J of PHarmacy and Pharmacology, vol. 51(4), pp 457-464, 1999.
Jedediah Bateman et al., “Comparison of Pharmacokinetic Properties of Omeprazole and Esomeprazole”, Pharmaceutics 1 (PSCI 423), Apr. 4, 2002.
“Esomeprazole—Proton Pump Inhibitors Revisted”, RGH Pharmacy E-Bulletin, vol. 10 (7): Jun. 16, 2003.

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