Enantioconvergent chemoenzymatic synthesis of ( R...

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

Reexamination Certificate

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C435S128000, C435S132000, C435S141000, C435S155000

Reexamination Certificate

active

07374926

ABSTRACT:
The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.

REFERENCES:
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patent: 51100026 (1976-09-01), None
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JP 51100026 A, Sep. 1976, Kurano, Masayasu, et al., CAS Abstract, AN:86:89207, 1 page.
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Takano, S. et al., “Practical Synthesis of (R)-Y-Amino-B-Hydroxybutanoic Acid (Gabob) From (R)-Epichlorohydrin,” Tetrahedron Lett., 28, 1783 (1987).
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Kurano et al., “Optical resolution of 4-amino-3-hydroxybutyramide,” Chem. Abstr. 86, 89207u (1977). (no translation: only title and 1- and d-GABOB species considered).
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Wang et al., Tetrahedron: Asymmetry 1999, 10: pp. 1895-1901.
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