Enamel matrix protein composition for treatment of systemic...

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from musculoskeletal system – other than cardiac muscle

Reexamination Certificate

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Details

C424S548000, C514S002600, C514S021800

Reexamination Certificate

active

07897180

ABSTRACT:
The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune response. The composition can be used in preventing and/or treating a condition or disease in a mammal that is characterised by said mammal presenting an imbalance in its native immune response to an internal and/or external stimuli, i.e. wherein at least a part of said mammal's immune system is stimulated non-discriminatingly, reacts hypersensitively to said immunogen, or fails to react to said stimuli. Said condition can typically either be systemic or local, such as a systemic and/or post-traumatic whole-body inflammation or an autoimmune disease.

REFERENCES:
patent: 6503539 (2003-01-01), Gestrelius et al.
patent: 6720009 (2004-04-01), Gestrelius et al.
patent: 6979670 (2005-12-01), Lyngstadaas et al.
patent: 1297356 (2001-05-01), None
patent: 2050158 (1995-12-01), None
patent: WO 99/43344 (1999-09-01), None
P. Nikolopoulos et al., “J. Clin. Periodontol”, 25:715-720 (1998).
S. Foster, “Journal Of Bacteriology”, 174(s): 464-470 (1992).
S. Gestrelius et al., “J. Clin Periodontol”, 24:685-692 (1997).
A. Hoang, et al., “Periodontol”, 71(8):1270-1277 (2000).

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