Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai
Patent
1994-02-03
1995-04-18
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Halogenated hydrocarbon doai
514 78, 514757, 514937, 514941, 514943, A61K 31035, A61K 3102, A61K 31685
Patent
active
054079624
ABSTRACT:
Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
REFERENCES:
patent: 2055083 (1936-09-01), Klein et al.
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3793450 (1974-02-01), Schnell
patent: 3823091 (1974-07-01), Samejima et al.
patent: 3911138 (1975-10-01), Clark, Jr.
patent: 3914294 (1975-10-01), Bernstein et al.
patent: 3942527 (1976-03-01), Li
patent: 3958014 (1976-05-01), Watanabe et al.
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 3975512 (1976-08-01), Long, Jr.
patent: 3989843 (1976-11-01), Chabert et al.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4105798 (1978-08-01), Moore et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4252827 (1981-02-01), Yokoyama et al.
patent: 4285928 (1981-08-01), Wada et al.
patent: 4325972 (1982-04-01), Geyer et al.
patent: 4366169 (1982-12-01), White
patent: 4395393 (1983-07-01), Schmolka
patent: 4397870 (1983-08-01), Sloviter
patent: 4423061 (1983-12-01), Yokoyama et al.
patent: 4423077 (1983-12-01), Sloviter
patent: 4425347 (1984-01-01), Yokoyama et al.
patent: 4443480 (1984-04-01), Clark, Jr.
patent: 4446154 (1984-05-01), Osterholm
patent: 4452818 (1984-06-01), Haidt
patent: 4461717 (1984-07-01), Moore
patent: 4486417 (1984-12-01), Sugimoto et al.
patent: 4497829 (1985-02-01), Sloviter
patent: 4526969 (1985-07-01), Yokoyama et al.
patent: 4534978 (1985-08-01), Yokoyama et al.
patent: 4542147 (1985-09-01), Yokoyama et al.
patent: 4562183 (1985-12-01), Tatlow et al.
patent: 4569784 (1986-02-01), Moore
patent: 4591599 (1986-05-01), Yokoyama et al.
patent: 4599343 (1986-07-01), Yokoyama et al.
patent: 4657532 (1987-04-01), Osterholm
patent: 4833274 (1989-05-01), Caporiccio et al.
patent: 4865836 (1989-09-01), Long, Jr.
R. Jeppsson, "Comparison of Pharmacological Effects of Some Local Anaesthetic Agents when using Water and Lipid Emulsion as Injection Vehicles", Acta Pharmacol. et Toxicol., 36, pp. 299-311 (1975).
R. Jeppsson, "Parabolic Relationship between Lipophilicity and Biological Activity of Aliphatic Hydrocarbons, Ethers and Ketones after Intravenous Injections of Emulsion Formulations into Mice", Acta Pharmacol. et Toxicol., 37, pp. 56-64 (1975).
R. Jeppsson and S. Ljungberg, "Anticonvulsant Activity in Mice of Diazepam in an Emulsion Formulation for Intravenous Administration", Acta Pharmacol. et Toxicol., 36, pp. 312-320 (1975).
R. Jeppsson and S. Rossner, "The Influence of Emulsifying Agents and of Lipid Soluble Drugs on the Fractional Removal Rate of Lipid Emulsions from the Blood Stream of the Rabbit", Acta Pharmacol. et Toxicol., 37, pp. 134-144 (1975).
R. Jeppsson and G. I. Schoefl, "The Ultrastructure of Lipid Particles in Emulsions Prepared with Various Emulsifiers", Aust. J. Exp. Biol. Med. Sci., 52, pp. 697-702 (1974).
R. Jeppsson and B. Sjoberg, "Compatibility of Parenteral Nutrition Solutions when mixed in a Plastic Bag", Clin. Nutr., 2 pp. 149-158 (1984).
R. Jeppsson et al., "Particle Size Distribution of a Fluorochemical Emulsion", in Proceedings of the HS Symposium on Perfluorochemicals in Medicine and Biology, Huddinge, Sweden, Apr. 28-29, 1977, V. Novakova et al., eds., pp. 108-113 (1977).
S. Ljungberg and R. Jeppsson, "Intravenous Injection of Lipid Soluble Drugs", Acta Pharm. Suecica, 7, pp. 435-440 (1970).
H. Ohyanagi and Y. Saitoh, "Development and Clinical Application of Perfluorochemical Artificial Blood", Int. J. Artificial Organs, 9, pp. 363-368 (1986).
A Wretlind, "Current Status of Intralipid and Other Fat Emulsions", in Fat Emulsions Parenter, Nutr., H.-C. Meng et al., eds., American Medical Association, Chicago, Ill., pp. 109-122 (1976).
A Wretlind, "Development of Fat Emulsions", J. Parenter. Enteral Nutr., 5, pp 230-250 (1981).
K. Yokoyama et al., "A Perfluorochemical Emulsion as an Oxygen Carrier", Artificial Organs, 8, pp. 34-40 (1984).
D. E. Hammerschmidt and G. M. Vercelloti, "Limitation of Complement Activation by Perfluorocarbon Emulsions: Superiority of Lecithin Emulsified Preparations", Chemical Abstracts, vol. 109, Abstract 197120n (1988).
M. B. Forman et al., "Reduction Of Infarct Size With Intracoronary Perfluorochemical In A Canine Preparation Of Reperfusion", Circulation, 71, pp. 1060-1068 (1985).
C. C. Jaffe et al., "Preservation Of Left Ventricular Ejection Fraction During Percutaneous Transluminal Coronary Angioplasty"By Distal Transcatheter Coronary Perfusion Of Oxygnated Fluosol DA 20%, Am. Heart J., 115, pp. 1156-1164 (1988).
T. Kawamura et al., "A New Simple Two Layer (Euro-Collins' Solution/Perfluorochemical) Cold Storage Method For Pancreas Preservation", Transplantation Proc., 21, pp. 1376-1377 (1989).
J. L. Osterholm et al., "Severe Cerebral Ischemia Treatment By Ventriculosubarachnoid Perfusion With An Oxygenated Fluorocarbon Emulsion", Neurosurg., 13, pp. 381-387 (1983).
S. J. Peerless et al., "Protective Effects Of Fluosol-DA In Acute Cerebral Ischemia", Stroke, 12, pp. 558-563 (1981).
S. J. Peerless et al., "Modification Of Cerebral Ischemia With Fluosol", Stroke, 16, pp. 38-43 (1985).
S. Rockwell et al., "Reactions Of Tumors And Normal Tissues In Mice To Irradiation In The Presence And Absence Of a Perfluorochemical Emulsion", Int. J. Radiation Oncology Biol. Phys., 12, pp. 1315-1318 (1986).
L. D. Segel and Rendig, "Isolated working Rat Heart Perfusion With Perfluorochemical Emulsion Fluosol-43", Am. J. Physiol., 242, pp. H485-H489 (1982).
L. D. Segel et al., "Prolonged Support Of Working Rabbit Hearts Using Fluosol-43 Or Erythrocyte Media", Am. J. Physiol., 252, pp. H349-H359 (1987).
L. D. Segel and Ensunsa, "Albumin Inproves Stability And Longevity Of Perfluorochemical-Perfused Hearts", Am. J. Physiol. 254, pp. H1105-H1112 (1988).
C. W. Song et al., "Increased Radiosensitivity of Tumors by PerFluorochemicals And Carbogen", Int. J. Radiation Oncology Biol. Phys., 11, pp. 1833-1836 (1985).
Suzuki et al., "Long-Lasting Drug Microparticles"Chemical Abstracts, vol. 85, Abstract 25402a (1976).
B. A. Teicher and C. M. Rose, "Oxygen-Carrying Perfluorochemical Emulsion As An Adjuvant To Radiation Therapy In Mice", Cancer Research, 44, pp. 4285-4288 (1984).
B. A. Teicher and C. M. Rose, "Perfluorocemical Emulsions Can Increase Tumor Radiosensitivity", Science, 223, pp. 934-936 (1984).
B. A. Teicher and C. M. Rose, "Effects of Dose And Scheduling On Growth Delay Of The Lewis Lung Carcinoma Produced By The Perfluorochemical Emulsion, Fluosol-DA", Int. J. Radiation Oncology Biol. Phys., 12, pp. 1311-1113 (1986).
B. A. Teicher et al., "Effect Of Various Oxygenation Conditions And Fluosol-DA On Cytotoxicity And Antitumor Activity Of Bleomycin In Mice", J. Natl. Cancer Inst., 80, pp. 599-603 (1988).
R. Virmani et al., "Myocardial Protection By Perfluorochemical Infusion During Transient Ischemia Produced By Balloon Coronary Occlusion", Am. Heart J., 116, pp. 421-431 (1988).
A. Wretlind and B. Ajaxon, "Stabilized Fat Emulsions For Parenteral Nutrition And Artificial Blood", Chemical Abstracts, vol. 107, Abstract 183567k (1987).
A. Wretlind et al., "A Nutritive Artificial Blood Emulsion Having Oxygen-Transporting Properties", Chemical Abstracts, vol. 107, Abstract 161694x (1987).
Kaufman Robert J.
Richard Thomas J.
Elrifi Ivor R.
Haley, Jr. James F.
HemaGen/PFC
Hollinden Gary E.
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