Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-10-31
2006-10-31
Webman, Edward J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S484000, C424S486000, C424S487000
Reexamination Certificate
active
07128927
ABSTRACT:
The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects the biologically active agent from being destroyed by the controlled release composition. The biologically active mixture includes the biologically active agent and a pharmaceutically acceptable protective carrier. The controlled release formulation includes a pharmaceutically acceptable, biodegradable, matrix forming material that is substantially insoluble in aqueous or body fluids and a pharmaceutically acceptable organic solvent. The biologically active mixture is combined with the controlled release formulation to form an emulsion, the delivery composition, which is then administered to a patient. The protective carrier can be an aqueous substance, a non-aqueous substance or a combination of both. The matrix forming material can be a polymeric material, a non-polymeric material or a combination of both. The organic solvent can have a solubility ranging from a high water solubility to a low water solubility.
REFERENCES:
patent: 2155658 (1939-04-01), Herrmann et al.
patent: 3068188 (1962-12-01), Beste et al.
patent: 3218283 (1965-11-01), Miller
patent: 3219527 (1965-11-01), Gurney
patent: 3328246 (1967-06-01), Gottfried et al.
patent: 3463158 (1969-08-01), Schmitt et al.
patent: 3520949 (1970-07-01), Shepherd et al.
patent: 3696811 (1972-10-01), Chen
patent: 3755558 (1973-08-01), Schribner
patent: 3760034 (1973-09-01), Critchfield et al.
patent: 3767784 (1973-10-01), Gluck
patent: 3887699 (1975-06-01), Yolles
patent: 3919773 (1975-11-01), Freeman
patent: 3931678 (1976-01-01), O'Sullivan et al.
patent: 3935308 (1976-01-01), Wise et al.
patent: 3939111 (1976-02-01), Schollenberger et al.
patent: 3949073 (1976-04-01), Daniels et al.
patent: 3975350 (1976-08-01), Hudgin et al.
patent: 4148871 (1979-04-01), Pitt et al.
patent: 4161948 (1979-07-01), Bichon
patent: 4265247 (1981-05-01), Lenz et al.
patent: 4294753 (1981-10-01), Urist
patent: 4408023 (1983-10-01), Gould et al.
patent: 4439420 (1984-03-01), Mattei et al.
patent: 4443430 (1984-04-01), Mattei et al.
patent: 4447562 (1984-05-01), Ivani
patent: 4450150 (1984-05-01), Sidman
patent: 4451452 (1984-05-01), Deibig et al.
patent: 4455256 (1984-06-01), Urist
patent: 4491479 (1985-01-01), Lauchenauer
patent: 4526909 (1985-07-01), Urist
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4563489 (1986-01-01), Urist
patent: 4568536 (1986-02-01), Kronenthal et al.
patent: 4570629 (1986-02-01), Widra
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4595713 (1986-06-01), St. John
patent: 4596574 (1986-06-01), Urist
patent: 4619989 (1986-10-01), Urist
patent: 4622219 (1986-11-01), Haynes
patent: 4631188 (1986-12-01), Stoy et al.
patent: 4650665 (1987-03-01), Kronenthal et al.
patent: 4652441 (1987-03-01), Okada et al.
patent: 4663077 (1987-05-01), Rei et al.
patent: 4677139 (1987-06-01), Feinmann et al.
patent: 4685883 (1987-08-01), Jernberg
patent: 4702917 (1987-10-01), Schindler
patent: 4715369 (1987-12-01), Suzuki et al.
patent: 4721613 (1988-01-01), Urquhart et al.
patent: 4745160 (1988-05-01), Churchill et al.
patent: 4761471 (1988-08-01), Urist
patent: 4767627 (1988-08-01), Caldwell et al.
patent: 4767861 (1988-08-01), Boulware
patent: 4772470 (1988-09-01), Inoue et al.
patent: 4774227 (1988-09-01), Piez et al.
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4780320 (1988-10-01), Baker
patent: 4789732 (1988-12-01), Urist
patent: 4793336 (1988-12-01), Wang
patent: 4795804 (1989-01-01), Urist
patent: 4800219 (1989-01-01), Murdoch et al.
patent: 4804691 (1989-02-01), English et al.
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4857456 (1989-08-01), Urist
patent: 4857602 (1989-08-01), Casey et al.
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4863472 (1989-09-01), Törmälä et al.
patent: 4894373 (1990-01-01), Young
patent: 4897268 (1990-01-01), Tice et al.
patent: 4902296 (1990-02-01), Bolander et al.
patent: 4904478 (1990-02-01), Walsdorf et al.
patent: 4905680 (1990-03-01), Tunc
patent: 4911931 (1990-03-01), Baylink
patent: 4912141 (1990-03-01), Kronman
patent: 4916241 (1990-04-01), Hayward et al.
patent: 4919939 (1990-04-01), Baker
patent: 4920203 (1990-04-01), Tang et al.
patent: 4921697 (1990-05-01), Peterlik et al.
patent: 4932973 (1990-06-01), Gendler
patent: 4933182 (1990-06-01), Higashi et al.
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4939131 (1990-07-01), Benedict et al.
patent: 4942157 (1990-07-01), Gall et al.
patent: 4946870 (1990-08-01), Partain, III et al.
patent: 4954298 (1990-09-01), Yamamoto et al.
patent: 4961707 (1990-10-01), Magnusson et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4981696 (1991-01-01), Loomis et al.
patent: 4983689 (1991-01-01), Yu
patent: 5007940 (1991-04-01), Berg
patent: 5013553 (1991-05-01), Southard et al.
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5077049 (1991-12-01), Dunn et al.
patent: 5149543 (1992-09-01), Cohen et al.
patent: 5176907 (1993-01-01), Leong
patent: 5188837 (1993-02-01), Domb
patent: 5192741 (1993-03-01), Orsolini et al.
patent: 5227157 (1993-07-01), McGinity et al.
patent: 5238714 (1993-08-01), Wallace et al.
patent: 5250584 (1993-10-01), Ikada et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5278201 (1994-01-01), Dunn et al.
patent: 5278202 (1994-01-01), Dunn et al.
patent: 5286763 (1994-02-01), Gerhart et al.
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5324520 (1994-06-01), Dunn et al.
patent: 5326568 (1994-07-01), Giampapa
patent: 5340849 (1994-08-01), Dunn et al.
patent: 5368858 (1994-11-01), Hunziker
patent: 5368859 (1994-11-01), Dunn et al.
patent: 4938763 (1995-07-01), Dunn et al.
patent: 5599552 (1997-02-01), Dunn et al.
patent: 5733950 (1998-03-01), Dunn et al.
patent: 5739176 (1998-04-01), Dunn et al.
patent: 5744153 (1998-04-01), Yewey et al.
patent: 5759563 (1998-06-01), Yewey et al.
patent: 6130200 (2000-10-01), Brodbeck et al.
patent: 6294204 (2001-09-01), Rossling et al.
patent: 6331311 (2001-12-01), Brodbeck et al.
patent: 1 261 549 (1989-09-01), None
patent: 29 17 037 (1979-04-01), None
patent: 0 140 766 (1985-05-01), None
patent: 0 159 293 (1985-10-01), None
patent: 0 169 016 (1986-01-01), None
patent: 0 171 173 (1986-02-01), None
patent: 0 241 178 (1987-10-01), None
patent: 0 244 118 (1987-11-01), None
patent: 0 271 831 (1988-06-01), None
patent: 0 297 535 (1989-01-01), None
patent: 0 430 474 (1991-06-01), None
patent: 0442671 (1991-08-01), None
patent: 0 537 559 (1993-04-01), None
patent: 0 539 751 (1993-05-01), None
patent: 0 560 014 (1993-09-01), None
patent: 0 586 838 (1994-03-01), None
patent: 0 649 662 (1995-04-01), None
patent: 2 126 270 (1972-10-01), None
patent: 2 635 685 (1990-03-01), None
patent: 2 017 113 (1979-10-01), None
patent: 2 223 027 (1990-03-01), None
patent: 63-137907 (1988-06-01), None
patent: WO 85/00969 (1985-03-01), None
patent: WO 85/02092 (1985-05-01), None
patent: WO 89/01006 (1989-02-01), None
patent: 95/27481 (1995-10-01), None
patent: 96/21427 (1996-07-01), None
patent: 97/15285 (1997-05-01), None
patent: WO 97/19676 (1997-06-01), None
patent: 98/27962 (1998-07-01), None
The Merck Index, 11th Ed, S. Budavari Ed., 1989, p. 1514.
Budavari, Susan , et al.,in The Merck Index, 12 Edition, Merck & Co., Inc. Whitehouse Station, NJ,(1996),p. 1636.
Hanks, Patrick,in The New Oxford Dictionary of English, Oxford, University Press,(1998),667 and 1288.
Shah, N. H., et al., “A Biodegradable Injectable Implant for Delivering Micro and Macromolecules using Poly (lactic-co-glycolic) Acid (PLGA) Copolymers”,Journal of Controlled Release, No. 2, Elsevier Science Publishers B.V.,(Mar. 26, 1993), 139-147.
Gref, R. et al., “Biodegradable long—circulating polymeric nanospheres”,Science, 263:1600-1602 (Mar. 18, 1994).
Holland, S. et al., “Polymers for biodegradable medical devices. 1. The potential of polyesters as controlled macromolecular release systems”,J
QLT USA, Inc.
Webman Edward J.
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