Emulsions

Details Emulsions Emulsions

1995-05-16

1997-05-06

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424450, 514 2, 514 3, 252302, 252308, A61K 966, A61K 3800

Patent

active

056268734

ABSTRACT:
A novel oil and water emulsion useful for delivery of a bioactive agent is disclosed. The emulsion comprises a first HLB requirement amount of surfactant dioleoyl phosphatidylethanolamine. In particular embodiments the emulsion includes a secondary surfactant other than dioleoyl phosphatidylethanolamine except in the limiting case wherein the HLB requirement is the HLB value of dioleoyl phosphatidylethanolemine in which case the the HLB requirement amount of a secondary surfactant is 0. By appropriate selection of dioleoyl phosphatidylethanolamine to secondary surfactant ratios, it is possible to prepare emulsions for pharmaceutical delivery of a bioactive agent using an oil phase having a required HLB value up to about 17.4. Above a required HLB value of about 17.4. dioleoyl phosphatidylethanolamine may be used to reduce the amount of secondary surfactant required to form an emulsion.

REFERENCES:
patent: 3934013 (1976-01-01), Paulsen
patent: 3992520 (1976-11-01), Gwatkin
patent: 3993073 (1976-11-01), Zaffaroni
patent: 4474912 (1984-10-01), Ozmeral
patent: 4533666 (1985-08-01), Matsumoto
patent: 4720353 (1988-01-01), Bell
patent: 4897355 (1990-01-01), Eppstein
patent: 5171737 (1992-12-01), Weiner
patent: 5204112 (1993-04-01), Hope
Trouet, Recent Results Cancer Res 75, 229-35, 1980.
Collins, Cancer Research 47, 735-39, 1987.
Griffin, et al., "Further Studies on Emulsion Systems", American Perfumer and Cosmetics, 81(9)1-8 (1966).
Madden, et al., "Stabilizaiton of Bilayer Structure for Unsaturated Phosphatidylethanolamines by Detergents", Biochemica et Biophysica Act, 684 (1982), 149-153.
Shinoda, et al., Emulsions and Solubilzation, 1986, John Wiley & Son, Inc. pp. 1-9, 55-93.
Tyle, "Liquid Crystals and Their Applications in Drug Delivery", from Controlled Release of Drugs: Polymers and Aggregate Systems, Morton Rosoff, ed, VCH Publishers(1989), pp. 125-162.
Weiner, "Lamellar Systems for Drug Solubilization", from Liposomes, From Biophysics to therapeutics, Ostro, ed., Marcel Dekker, Inc., New York, 1987.

Affiliated with

Also associated with

Rating

Emulsions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Emulsions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Emulsions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2130610