Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-03-03
1992-12-15
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514938, 514944, 514975, A61K 9107, A61K 910, A61K 9113
Patent
active
051717379
ABSTRACT:
A novel oil and water emulsion useful for delivery of a bioactive agent is disclosed. The emulsion comprises a first HLB requirement amount of surfactant dioleoyl phosphatidylethanolamine. In particular embodiments the emulsion includes a secondary surfactant other than dioleoyl phosphatidylethanolamine except in the limiting case wherein the HLB requirement is the HLB value of dioleoyl phosphatidylethanolamine in which case the HLB requirement amount of a secondary surfactant is 0. By appropriate selection of dioleoyl phosphatidylethanolamine to secondary surfactant ratios, it is possible to prepare emulsions for pharmaceutical delivery of a bioactive agent using an oil phase having a required HLB value up to about 17.4. Above a required HLB value of about 17.4. dioleoyl phosphatidylethanolamine may be used to reduce the amount of secondary surfactant required to form an emulsion.
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The HLB System a time-saving guide to emulsifier selection, ICI Americas Inc., 1976, revised Aug. 1984, pp. 2-20.
Hansrani, et al., "The Preparation and Properties of Sterile Intravenous Emulsions", 1984; J. Parent Sci. Tech. 37:145-150.
Carpenter-Green Sharon
Weiner Alan L.
Bloom Allen
Janofsky Ilene
Springer David B.
The Liposome Company Inc.
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