Emulsioin suitable for administering a poorly water-soluble phot

Details Emulsioin suitable for administering a poorly water-soluble phot Emulsioin suitable for administering a poorly water-soluble phot

1995-04-11

1997-04-01

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514450, A61K 9127, A61K 3140

Patent

active

056163428

ABSTRACT:
Emulsion comprising a lipoid as a hydrophobic phase dispersed in a hydrophilic phase, a poorly water-soluble photosensitizing compound, surfactant, and as a cosurfactant a salt of a bile acid is provided that is suitable for administering to a patient.

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Richter et al., Liposomal Delivery of a Photosensitizer, Benzoporphyrin Derivative Monoacid Ring A (BPD), to Tumor Tissue in a Mouse Tumor Model, Photochemistry and Photobiology, vol. 57, No. 6, (1993), pp. 1000-1006.
Cannon, Journal of Pharmaceutical Sciences, Pharmaceutics and Drug Delivery Aspects of Heme and Porphyrin Therapy, Journal of Pharmaceutical Sciences, vol. 83, No. 5 (1993), pp. 435-446.
Benita et al., Physostigmine emulsion: a new injectable controlled release delivery system, International Journal of Pharmaceutics, vol. 30, (1986), pp. 47-55.
Schuberth et al., Intravenous Infusion of Fat Emulsions, Phosphatides and Emulsifying Agents, ACTA Chirurgica Scandinavica Supplementum 278, pp. 3-21.

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