Empty canine parvovirus capsids having CPV recombinant VP2 and v

Details Empty canine parvovirus capsids having CPV recombinant VP2 and v Empty canine parvovirus capsids having CPV recombinant VP2 and v

1994-10-04

1999-03-16

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241991, 424818, 530418, 530419, A61K 39215

Patent

active

058826521

ABSTRACT:
The present invention is a method for the production of a subunit vaccine against canine parvovirus (CPV). The method includes the step wherein a recombinant protein VP2 of CPV is obtained by using the replication of a recombinant baculovirus wherein the gene corresponding to VP2 has been previously inserted in cells of a permissive host. The protein VP2 obtained has the capacity of forming empty VP2 capsids with high immunogenicity and can be provided as a vaccine formulation for protecting dogs against CPV infection the recombinant baculovirus AcMNPV.pCPVEx17 expresses the VP2 of CPV in conditions making possible the formulation of pseudo-viral capsids.

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Kajigaya et al. PNAS (88):4646-4650 Jun. 1991.
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