Employing strains of E. coli expressing non-indigenous adhesins

Details Employing strains of E. coli expressing non-indigenous adhesins Employing strains of E. coli expressing non-indigenous adhesins

1989-02-06

1992-08-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 92, 43525233, 4351723, 435 693, A61K 39108, C12N 121, C12N 1500

Patent

active

051377217

ABSTRACT:
A vaccine is described for prevention of gastro-enteric disease caused in a mammalian species by a pathogenic microorganism. The vaccine comprises a non-pathogenic microorganism strain containing stable replicative plasmids, each having one or more genes non-indigenous to the plasmid. The non-indigenous genes are either genes for an adhesin necessary for adherence of the pathogenic microorganism in the mammalian species or are genes for toxoids of toxins causative of the disease. Both types of genes may also be included in the same plasmid.

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