Emetic tetralones and the use thereof for inducing regurgitation

Details Emetic tetralones and the use thereof for inducing regurgitation Emetic tetralones and the use thereof for inducing regurgitation

1976-01-16

1977-12-20

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260574, A61K 31135, C07C 9116, C07C 9128

Patent

active

040642712

ABSTRACT:
5,6-Dialkoxy-2-tetralones (I) are disclosed as useful intermediates in the synthesis of 2-amino-5,6-dialkoxytetralins (III) and 2-amino-5,6-dihydroxytetralins (IV). Compounds of the groups III and IV are potent emetics.

REFERENCES:
patent: 2632024 (1953-03-01), Grob
patent: 3574762 (1971-04-01), Nagato et al.
J. D. McDermed et al., J. Med. Chem. 18, 362 (1975).
Cannon, et al., Journal of Med. Chem. 1972, vol. 15, No. 4, pp. 348-350.
W. K. Sprenger et al., Journal of Med. Chem. vol. 12, pp. 487-490 May 1969.
J. G. Cannon et al., J. Het. Chem. Aug. 1972, pp. 959-962.

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