Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-02-02
2010-11-09
Pak, Michael (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000
Reexamination Certificate
active
07829527
ABSTRACT:
The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.
REFERENCES:
patent: 6653460 (2003-11-01), Newcomb et al.
patent: 7109175 (2006-09-01), Bkaily et al.
Arroyo et al., SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells. Eur J Pharmacol. Aug. 15, 2003;475(1-3):11-8.
Barker et al., Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a metaanalysis. J Neurosurg. Mar. 1996;84(3):405-14.
Ishiguro et al., Enhanced myogenic tone in cerebral arteries from a rabbit model of subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. Dec. 2002;283(6):H2217-25.
Ishiguro et al., Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage. Circ Res. Mar. 4, 2005;96(4):419-26.
Ishiguro et al., The emergence of a Ca2+ channel with distinct biophysical properties in cerebral arteries following subarachnoid hemorrahage. Experimental Biology. Washington, D.C. Apr. 17-21, 2004. Abstract 671.15.
Ishiguro et al., Altered Ca2+ channel properties in cerebral arteries following subarachnoid hemorrhage. Experimental Biology: Translating the Genome. San Diego, CA. Apr. 11-15, 2003. Abstract 315.5.
Kuzmiski et al., Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels. Epilepsia. Apr. 2005;46(4):481-9. Abstract Only.
Newcomb et al., Selective peptide antagonist of the class E calcium channel from the venom of the tarantulaHysterocrates gigas. Biochemistry. Nov. 3, 1998;37(44):15353-62.
Piedras-Rentería et al., Antisense oligonucleotides against alpha1E reduce R-type calcium currents in cerebellar granule cells. Proc Natl Acad Sci U S A. Jun. 23, 1998; 95(13):7760-5.
Wellman, Cerebral artery Ca2+ signaling & subarachnoid hemorrhage. Grant Award Date: Nov. 29, 2004. Project Start Date: Dec. 1, 2004. Grant Abstract.
Ishiguro Masanori
Wellman George C.
Pak Michael
University of Vermont and State Agricultural College
Wolf Greenfield & Sacks P.C.
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