Embryonic stem cells

Details Embryonic stem cells Embryonic stem cells

2005-04-05

2005-04-05

Woitach, Joseph (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S001100

Reexamination Certificate

active

06875607

ABSTRACT:
The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.

REFERENCES:
patent: 5843780 (1998-12-01), Thomson
patent: 6200806 (2001-03-01), Thomson
patent: 6280718 (2001-08-01), Kaufman et al.
patent: WO9622362 (1996-07-01), None
patent: WO9732033 (1997-09-01), None
patent: WO 98 0784 1 (1998-02-01), None
patent: WO9843679 (1998-10-01), None
JA Thomson et al., TIBTECH, “Human embryonic stem cell and embryonic germ cell lines,” Feb. 2000, vol. 18, pp. 53-57.*
J Nichols et al., Development, “Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity,” 1990,110, pp. 1341-1348.*
AJ Clark et al., Transgenic Animals, “Germ line manipulation: applications in agriculture and biotechnology,” pp. 249-250.*
JA Piedrahita et al., Theriogenology, “On the Isolation of Embryonic Stem Cells: Comparative Behavior of Murine,Porcine and Ovine Embryos,” Nov. 1990, vol. 34, No. 5, pp. 879-901.*
JS Odorico et al., Stem Cells, “Multilineage Differentiation from Human Embryonic Stem Cell Lines,” 2001; 19:193-204.*
YP Cruz et al., Animal Applications of Research in Mammalian Development, “Origin of Embryonic and Extraembryonic Cell Lineages in Mammalian Embryos,” pp. 147-204.*
Bongso, A., et al. (1994) “The Growth of Inner Cell Mass Cells From Human Blastocysts”, Theriogenology, Los Altos, CA, US, vol. 41, pp. 167.
Pera, M.F., et al. (1999) “Human Embryonic Stem Cells”, Journal of Cell Science, Essex, GB, vol. 113, pp. 5-10.
Reubinoff, B.E., et al. (2000) “Embryonic Stem Cell Lines from Human Blastocysts: Somatic Differentation in Vitro”, Nature Biotechnology, vol. 18, No. 4, pp. 399-404.
Thomas, J.A., et al., “Neural Differentation of Rhesus Embryonic Stem Cells”, Apmis, Copenhagen, DK, vol. 106, 1998, pp. 149-156.
Li F., et al., “Hematopietic Differentation In Vitro of Rhesus Monkey Embryonic Stem Cells”, Blood, W.B. Saunders, Philadelphia, VA, US, vol. 92, No. 10 Suppl. 1, par. 15, Nov. 1998, p. 368A.
Rathjen, P.D., et al., “Properties and Uses of Embryonic Stem Cells: Prospects for Application to Human Biology and Gene Therapy”, Reproduction and Fertility and Development, CSIRO, East Melbourne, AU, vol. 19, No. 1, pp. 31-47.
Pederson, R.A., “Studies of In Vitro Differentation with Embryonic Stem Cells”, Reproduction, Fertility and Development, CSIRO, East Melbourne, AU, vol. 6, No. 5, 1994, pp. 543-552.
Brook, F.A., et al., “The Origin and Efficient Derivation of Embryonic Stem Cells in the Mouse”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, US, vol. 94, May 1997, pp. 5709-5712.
Evans, M. J., et al., (1981) “Establishment in culture of pluripotential cells from mouse embryos”,Nature 292:154-156.
Martin, G. R., (1981) “Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells”,Proc. Natl. Acad. Sci USA 78(12):7634-7638.
Andrews, P. W., et al. (1984) “Pluripotent Embryonal Carcinoma Clones Derived from the Human Teratocarcinoma Cell Line Tera-2”,Lab. Invest. 50(2):147-162.
Pera, M. F., et al. (1989) “Isolation and characterization of a multipotent clone of human embryonal carcinoma-cells”,Differentiation 42:10-23.
Thomson, J. A., et al. (1995) “Isolation of a primate embryonic stem cell line”,Proc. Natl. Acad. Sci USA 92:7844-7848.
Thomson, J. A., et al. (1996) “Pluripotent Cell Lines Derived from Common Marmoset (Callithrix jacchus) Blastocysts”,Bio Reprod. 55:254-259.
Bongso, A., et al. (1994) “Isolation and culture of inner cell mass cells from human blastocysts”,Hum. Reprod. 9(11):2110-2117.
Andrews, P. W., et al. (1996) “Comparative analysis of cell surface antigens expressed by cell-lines derived from human germ cell tumours”,Int. J. Cancer 66:806-816.
Cooper, S., et al. (1992) “A novel keratan sulfate proteoglycan from a human embryonal carcinoma cell line”,Biochem.J. 286:959-966.
Pera, M. F., et al. (1988) “Analysis of cell-differentiation lineage in human teratomas using new monoclonal antibodies to cytostructural antigens of embryonal carcinoma cells”,Differentiation 39:139-149.
Fong, C. Y., et al. (1998) “Comparison of human blastulation rates and total cell number in sequential culture media with and without co-culture”,Hum. Reprod. 14(3):774-781.
Fong, C. Y., et al. (1997) “Ongoing normal pregnancy after transfer of zona-free blastocyts: implications for embryo transfer in the human”,Hum. Reprod. 12(3):557-560.
Solter, D., et al. (1975) “Immunosurgery of mouse blastocyst”,Proc. Natl Acad Sci USA 72(12):5099-5102.
Vajta, G., et al. (1998) “Open Pulled Straw (OPS) Vitrification: A New Way to Reduce Cryoinjuries of Bovine Ova and Embryos”,Molecular Reproduction and Development 51:53-58.
Vajta, G., et al. (1998) “Sterile application of the opened pulled straw (OPS) vitrification method”,Cryo-letters 19:389-392.
Kleinsmith, L. J., et al. (1964) “Multipotentiality of Single Embryonal Carcinoma Cells”,The University of Michigan 24:1544-1551.
Stevens, L. C. (1983) “Testicular, ovarian, and embryo-derived teratomas”,Cancer Surveys 2(1):75-91.
Martin, G. R. (1980) “Teratocarcinomas and Mammalian Embryogenesis”,Science 209:768-776.
Matsui, Y., et al. (1992) “Derivation of Pluripotential Embryonic Stem Cells from Murine Primordial Germ Cells in Culture”,Cell 70:841-847.
Thompson, S., et al. (1984) “Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid”,F. Cell Sci. 72:37-64.
Pirty, M., et al., “Embryonic Stem Cells, Creating Transgenic Animals”,Methods in Cell Biology,Academic Press, pp. 279-293.
Shamblott, M. J., et al., (1998) “Derivation of pluripotent stem cells from cultured human primordial germ cells”,Proc. Natl. Acad. Sci., 95:13726-13731.
Svendsen, C. N., et al., (1999) “New prospects for human stem-cell therapy in the nervous system”,Trends in Neurosciences, 22(8):357-364.
Thomson, J. A., et al., (1998) “Embryonic Stem Cell Lines Derived From Human Blastocysts”,Science, 282:1145-1147.

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