Embryonic cell populations and methods to isolate such populatio

Details Embryonic cell populations and methods to isolate such populatio Embryonic cell populations and methods to isolate such populatio

1995-12-11

1999-02-23

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435354, 435355, 435385, 435386, C12N 510, C12N 506

Patent

active

058743014

ABSTRACT:
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth for therapeutic and experimental use.

REFERENCES:
Breier et al., "Expression of Vascular Endothelial Growth Factor During Embryonic Angiogenesis and Endothelial Cell Differentiation", pp. 521-532, 1992, Development, vol. 114.
Burkert et al., Early Fetal Hematopoietic Development From in vitro Differentiated Embryonic Stem Cells, pp. 698-708, 1991, New Biologist, vol. 3, No. 7.
Gutierrez-Ramos et al., "In vitro Differentiation of Embryonic Stem Cells into Lymphocyte Precursors Able to Generate T and B Lymphocytes in vivo", pp. 9171-9175, 1992, Proc. Natl. Acad. Sci. USA, vol. 89, Oct.
Hawley et al., "The HOX11 Homeobox-Containing Gene of Human Leukemia Immortalizes Murine Hematopoietic Precursors", pp. 1-12, 1994, Oncogene, vol. 9.
Keller et al., "Hematopoietic Commitment During Embryonic Stem Cell Differentiation in Culture", pp. 473-486, 1993, Mol. Cell. Biol., vol. 13, No. 1.
Schmitt et al., "Hematopoietic Development of Embryonic Stem Cells in vitro: Cytokine and Receptor Gene Expression", pp. 728-740, 1991, Genes & Dev., vol. 5.
Wang et al., Embryonic Stem Cell-Derived Cystic Embryoid Bodies Form Vascular Channels: An in vitro model of Blood Vessel Development, pp. 303-316, 1992, Development, vol. 114.
Wiles et al., "Multiple hemataopoietic lineages develop from embryonic stem (ES) cells in culture", Development 111, 259-267, 1991.

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