Embryo modification and implantation

Details Embryo modification and implantation Embryo modification and implantation

2003-04-07

2010-10-26

Gilbert, Samuel G (Department: 3735)

Surgery

Reproduction and fertilization techniques

Embryo transplantation

Reexamination Certificate

active

07819796

ABSTRACT:
The present invention relates to constructs and methods used to enhance the attachment and implantation of an embryo. It is shown that modified glycolipids and glycolipid-attachment molecule constructs can be used to modify embryos, or localised to target tissues, to enhance interaction between the embryo and the target tissue, (typically the endometrium). The invention may advantageously be used to enhance implantation of embryos in the uterus, for example, in IVF treatments.

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Taylor et al., “Complement-binding proteins are strongly expressed by human preimplantaion blastocysts and cumulus cells as well as gametes”, Molecular Human Reproduction, 2(1), 52-59, 1996.
Zhu et al., “Glycosphingolipids of rabbit endometrium and their changes during pregnancy”, J. Reprod. Fert. 95, 813-823.
Taylor, C.T., et al; “Complement-binding proteins are strongly expressed by human preimplantation blastocysts and cumulus cells as well as gametes”;Molecular Human Reproduction, vol. 2, No. 1, pp. 52-59 (1996).
Zhu, Z., et al; “Clycosphingolipids of rabbit endometrium and their changes during pregnancy”;Journals of Reproduction&Fertility Ltd., vol. 95; pp. 813-823 (1992).
Simon, C., et al; “Early pregnancy losses in in vitro fertilization and oocyte donation”;Fertility and Sterility, vol. 72, No. 6, pp. 1061-1065 (1999).

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