Embolization plugs for blood vessels

Surgery – Instruments – Internal pressure applicator

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514773, 128DIG8, A61L 1500

Patent

active

054566932

ABSTRACT:
A bioresorbable and hemostatic plug for embolization made from a collagen piece is compressed so as to be longitudinally insertable into a tubular biological vessel such as a blood vessel to be occluded. The collagen piece is capable of expanding radially inside the vessel by absorbing fluid such as the blood and thereby providing mechanical fixation in and occlusion of the vessel. Two such collagen pieces may be used with a spacer of a different material in between. Different kinds of therapeutic agents can be bonded to or physically absorbed by the collagen pieces so as to be delivered to the site of occlusion.

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patent: 4703108 (1987-10-01), Silver et al.
patent: 4749689 (1988-06-01), Miyata et al.
Carlos E. Encarnacion, et al.: "Subselective Embolization with Gelatin Sponge through an Open-ended Guide Wire", Radiology, vol. 174, No. 1, p. 265 (1990).
A. H. Matsumoto, P. V. Suhocki, and K. H. Barth: "Superselective Gelfoam Embolotherapy Using a Highly Visible Small Caliber Catheter", Cardio Vascular and Interventional Radiology (1988) vol. 11, 303-306.
K. H. Barth, J. D. Strandberg, and R. I. White: "Long Term Follow-Up of Transcatheter Embolization With Autologous Clot, Oxycel and Gelfoam in Domestic Swine", Investigative Radiology (1977) vol. 1, 273.
A. Berenstein and E. Russell: "Gelatin Sponge in Therapeutic Neuroradiology": Neuroradiology (1981) vol. 141, 105-112.

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