Embolic material for endovascular occlusion of abnormal vasculat

Details Embolic material for endovascular occlusion of abnormal vasculat Embolic material for endovascular occlusion of abnormal vasculat

1997-10-07

1999-04-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424484, A61F 1300, A61K 914

Patent

active

058940227

ABSTRACT:
The present invention is an endovascular embolic composition. The embolic composition comprises a hydrophilic insoluble matrix having a microscopic mesh-like structure. The voids or intricacies of the matrix enclose droplets of aqueous solution as well as liquid oil. This structure is essentially equivalent to a "gel" structure with the insoluble matrix including both aqueous and oil droplets within its mesh. In creating the matrix a liquid oil base is mixed with an aqueous solution of a matrix base. The matrix base comprises an organic polymer such as a protein like albumin or its equivalent dissolved in an aqueous solution which may contain additional solutes. The matrix base solution is mixed and emulsified with the liquid oil base at a volume ratio ranging between about 1-to-1 and 1-to-5 respectively. To create the embolic composition the matrix base is then precipitated or cross-linked to form a gel with a mesh-like microscopic structure in which insoluble matrix surrounds and entraps both aqueous fluid and liquid oil. Preferably sclerifying agents are included within the composition so that scar tissue will develop to permanently occlude the embolized vasculature.

REFERENCES:
Scheffel et al. "Albumin Microspheres for Study of the Reticuloendothelial System," J. of Nuclear Medicine, vol. 13, No. 7, pp. 498-503, Jul. 1972.

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