Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-09-22
1996-11-19
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 21, 530326, 530350, 530362, 530380, 530416, 530829, 530856, A61K 3810, A61K 3816, C07K 708, C07K 1447
Patent
active
055762972
ABSTRACT:
Opossum whole serum exhibits a life saving property by neutralizing the lethality of venoms from all major families of poisonous snakes, and therefore an injection of Opossum serum can used as a novel treatment for many types of envenomation. Preferably, the injectable treatment for envenomation should be a composition obtained from the fraction of Opossum whole serum which contains the lethal toxin neutralizing factor, i.e. the so called "natural LTNF", in purity. A method is given for the manufacture of a lethal toxin neutralizing factor from the serum of an opossum (Didelphis virginiana) serum, by fractionating the opossum serum and isolating this select fraction from the plurality of fractions having an N terminal amino acid sequence given by SEQ ID No: 1. A short peptide was synthesized having SEQ ID No: 1. The synthetic peptide having sequence SEQ ID No: 1 shows lethal toxin neutralizing activity similar to the natural LTNF from opossum or mongoose sera. The synthetic LTNF also has life saving utility.
REFERENCES:
Bone "The Pathogenesis of Sepsis" Ann Int Med 115(6) 457-469 1991.
Guyton "Textbook of Medical Physiology" 8th Ed 269-271 1991.
Mousstach e et al "Mechanisms of Resistance of the Opossum to Some Snake Venoms" Toxicon 17(Suppl. 1) 130 1979.
Domont et al. "Natural Anti-Snake Venom Proteins" Toxicon 29(10) 1183-1194 1991.
Perales et al "Neutralization of the Oedematogenic activity of Bothrops Jararaca venom on the Mouse Paw by an antibothropic Fraction Isolated from Opossum serum" Agents Actions 37(3-4) 250-259 1992.
Tomihara et al. "Purification of Three Antihemorrhagic Factors From The Serum of A Mongoose" Toxicon 25(6) 685-689 1987.
Perates et al. "Anti Snake Venom Protein from Didelphidae" Abstract 10th World Congress. Toxicon 30(5-6) 543 1992.
Menchaca et al. "The Purification & Characterization of An Antihemerrhagic Factor in Opossum Serum" Toxicon 19(5) 623-632 1981.
Lipps Binie V.
Lipps Frederick W.
Casperson John R.
Degen Nancy J.
Fleisher Mindy
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