Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-10-23
2007-10-23
Gupta, Anish (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
11069849
ABSTRACT:
Embedder compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes an embedder peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the embedder peptide converts to a non-ionic lipophilic form effective to embed into membranes of cells. Each composition also includes a cargo component which cannot be pulled across cell membranes by the embedder peptide and which is effective for detecting or killing cells in whose membranes the embedder peptide has embedded.
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Friedman Lori M.
Gene Tools, LLC
Gudibande Satyanarayana R.
Gupta Anish
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