Elution test method and apparatus

Details Elution test method and apparatus Elution test method and apparatus

2008-07-01

2008-07-01

Stafira, Michael P. (Department: 2886)

Optics: measuring and testing

For light transmission or absorption

C356S436000

Reexamination Certificate

active

07394544

ABSTRACT:
An elution test method measures the elution process of a specific component in a process where a preparation containing at least the specific component subject to a change with time in chemical properties after elution and an impurity component not subject to a change with time in chemical properties after elution is eluted into a test liquid. The method obtains a ratio of absorbance k of the impurity component and a ratio of absorbance k′ of the specific component at two isosbestic point wavelengths λ1, λ2in a spectrum including the specific component and its decomposed matter, and calculates at least one of the absorbances A1(t), A2(t) of said specific component by using k×C2(t)−C1(t)=k×A2(t)−A1(t) and A1(t)/A2(t)=k′ from the absorbance C1(t), C2(t) at said two isosbestic point wavelengths λ1, λ2measured at the plural time points t in the elution process of said preparation, and converts the result to an elution concentration.

REFERENCES:
patent: 6542231 (2003-04-01), Garrett
patent: 2006/0204984 (2006-09-01), Bazan et al.

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