Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Patent
1995-06-07
1999-11-23
Feisee, Lila
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
514 21, 530344, 435 701, A61K 3400, A61K 3900, C07K 500, C12P 2102
Patent
active
059895659
ABSTRACT:
Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide complex on the surfaces of the cells, the method comprising incubating the cells in the presence of peptide elution buffer, preferably comprising iso-osmotic, citrate-phosphate buffer at a pH of approximately 3.3, for between about 15 seconds and one minute. Using these methods a naturally processed melanoma peptide recognized by CD8.sup.+ cytotoxic T lymphocytes has been identified.
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Lotze Michael T.
Storkus Walter J.
Bansal Geetha P.
Feisee Lila
University of Pittsburgh
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