Special receptacle or package – For mixing – Means to manipulate without rupture
Patent
1991-05-10
1994-03-08
Foster, Jimmy G.
Special receptacle or package
For mixing
Means to manipulate without rupture
206568, 215DIG8, B65D 8132
Patent
active
052919919
DESCRIPTION:
BRIEF SUMMARY
The present invention concerns an elongate container having two separate compartments, one being an extension of the other, the first of which contains a liquid and the second either a liquid, a powder or a lyophilisate, said substances to be mixed in the second compartment, said container comprising a central cylindrical throat in which there is an intermediary sealing plug for separating the two compartments when the container is being stored, as well as an open cylindrical neck of narrower section than those compartments, in which a movable sealing member is engaged comprising at least one active portion disposed to be displaceable between a first position called the storage position, in which it constitutes a sealing plug, and a second, ready for use position.
Containers with two compartments designed to respectively hold a liquid, a powder substance or a lyophilisate and a liquid solvent and which are separated during storage by a removable intermediate plug are already known, particularly in medical usage. Such a container is described, for example, in French Patent No. 1.044.686 which describes a tubular bottle with a V-shaped ring throat at the center in which an intermediate sealing plug is inserted for separating the two compartments. In some versions the bottle is open at both ends, which are stoppered with sealing plugs after filling the compartments, and in other versions the bottle is open only at one end. The bottle is essentially cylindrical along its entire length, except for the central annular ring holding the intermediate sealing plug.
This type of bottle has numerous disadvantages because of its construction. The annular ring has a slightly different interior diameter than that of the two cylindrical chambers disposed on one side and the other of the ring; this is to permit the intermediate sealing plug to be guided and positioned. But this construction is flawed. When the plug is pushed back to mix the components, if it tips obliquely, it may become blocked between the walls of the lower chamber, prevent the liquid from flowing and ultimately prevent mixing the components. This can happen because the bottle diameter is smaller than the diagonal measurement of the intermediate sealing plug.
The intermediate sealing plug is only held weakly in place by the rim. The seal between the two compartments is unreliable. Furthermore, inadvertent pressure exerted on the end plug causes displacement of the intermediate plug and risks accidental transfer of liquid from one compartment to the other.
It is also questionable how the end plug can be positioned without displacing the intermediate plug if the compartment between these two plugs is filled with liquid. Pressure necessarily exists in the bottle, thereby causing a twofold risk: that of making the bottle open and that of displacing the intermediate plug.
Finally, the embodiment illustrated in this patent does not guaranty an inviolable system. The end plugs are an ordinary type and may be opened and then replaced without the end user realizing it.
French Patent Application Publication No. 2 483 365 describes a vial for medicinal substances which, during storage, are in the form of two components isolated in two chambers separated by an intermediate sealing plug. Placement of the sealing plug is delicate because it cannot be pre-positioned in the vial neck. Moreover, the plug is essentially the same height as the narrow central throat where the plug is located, so that the latter must not undergo any axial displacement after positioning to avoid breaking the seal between the two chambers. As a result, the plug for the neck of the bottle must be positioned using special conditioning machines to allow evacuation of a volume of air substantially equivalent to the volume of the portion of the plug penetrating the neck, thereby eliminating pressure capable of axially displacing the intermediate sealing plug. Such machines are costly, cannot attain high speeds and require pressure control means.
To eliminate the use of such auxiliary equipment a su
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Becton Dickinson France S.A.
Foster Jimmy G.
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