Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-06-28
2011-06-28
Swope, Sheridan (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07968692
ABSTRACT:
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
REFERENCES:
patent: 4666701 (1987-05-01), Horrobin et al.
patent: 4758592 (1988-07-01), Horrobin et al.
patent: 4826877 (1989-05-01), Stewart et al.
patent: 4943674 (1990-07-01), Houck et al.
patent: 5106739 (1992-04-01), Comai et al.
patent: 5116871 (1992-05-01), Horrobin et al.
patent: 5175095 (1992-12-01), Martineau et al.
patent: 5188958 (1993-02-01), Moloney et al.
patent: 5196198 (1993-03-01), Shaw et al.
patent: 5420034 (1995-05-01), Kridl et al.
patent: 5443974 (1995-08-01), Hitz et al.
patent: 5463174 (1995-10-01), Moloney et al.
patent: 5484724 (1996-01-01), El-Sherbeini et al.
patent: 5552306 (1996-09-01), Thomas et al.
patent: 5589379 (1996-12-01), Kridl et al.
patent: 5700671 (1997-12-01), Prieto et al.
patent: 5750176 (1998-05-01), Prieto et al.
patent: 0296751 (1988-12-01), None
patent: 2648347 (1990-12-01), None
patent: WO88/07577 (1988-10-01), None
patent: WO93/11245 (1993-06-01), None
patent: WO94/11516 (1994-05-01), None
patent: WO95/24494 (1995-09-01), None
patent: WO96/13591 (1996-05-01), None
patent: WO98/39448 (1998-09-01), None
patent: WO98/46765 (1998-10-01), None
patent: WO00/12720 (2000-03-01), None
patent: WO01/59128 (2000-08-01), None
patent: WO00/70945 (2000-11-01), None
patent: WO02/08401 (2002-01-01), None
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
Altschul, et al., Nuc. Acids Res., 25:3389-3402 (1997).
Ausubel, et al., Short Protocols in Molecular Biology, Ch. 13:3-5(1992).
Brenner, et al., Adv. Exp. Med. Biol., 83:85-101 (1976).
Bowles, R.D., et al., Long-chain N-3 Polyunsaturated Fatty Acid Production by Members of . . . , Journal of Biotech.,vol. 70. No. 1-3, pp. 193-2002. XP004173399 ISSN:0168-1656.
Das, T, et al.,“Gamma.-Linolenic Acid Metabolism: Ident. and Char.of Gamma-Linolenic Acid Elong. Enzyme” Intl. Symp. of Gamma-Linolenic Acid, 2nd, San Diego, CA, Apr. 25-28, 2000.
Hashimo, K, “Mus Musculus Brain cDNA, Clone:MNCb-4912, 5′ end.” Database EMBL (online) Oct. 19, 1999, Database Accession No. AU079897 XP002223157.
Gietz, et al, Mol. Cell, Biol., 5:255-269 (1995).
Hoffman, et al, Gene, 57:267 (1987).
Horrobin, et al, Am. J. Clin. Nutr., vol. 57 (Suppl.) 732S-737S.
Hoveland, et al, Gene, 38:57-64 (1989).
Kendrick, A, et al, “Lipids of Selected Molds Grown for Production of N-3 and N-6 Polyunsaturated Fatty Acids,” Lipids, vol. 27, No. 1, 1992, pp. 15-20, XP002047887.
Knutzon, et al, J. Biol. Chem. 273:29360-29366 (1998).
Lassner, et al, The Plant Cell, 8:281-292 (1996).
Oh, et al, The Journal of Biological Chemistry, 272 (28):17376-17384 (1997).
Pearson & Lipman, Proc. Natl, Acad. Sci. USA, 85:2444-2448 (1998).
Salem, N, et al, “Arachidonic & Docosahexaenoic Acids are Biosynthesized from their 18-Carbon Precursors in Human Infants,” Natl. Acad. Sci. vol. 93, Jan. 1996, pp. 49-54.
Schnieke, et al, Science, 278:2130-2133 (1997).
Tvrdik, P, et al, “Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids,” Jour.Cell Biol.,vol. 149, No. 3(May 1, 2000), p. 707-717.
Pereira, S.A., “Ident. of Twonovel Microalgal Enzymes Involved in the Conv. of w3-Fatty Acid, eicosapentaenoic acid, into docosahexaenoic acid”, Biochem. J., 384:357-366(2004).
Tonon, T, at al, “Acyl-CoA Elongase Activity and Gene From the Marine Microalga Pavlova Lutheri(Haptophyceae),” Journ. of Appl. Phyco., 17:111-118(2005).
Office action from Canadian patent application No. 2,341,336, dated May 25, 2010.
Huang Yung-Sheng
Leonard Amanda Eun-Yeong
Mukerji Pradip
Pereira Suzette L.
Abbott Laboratories
Engle Mark R.
Swope Sheridan
Weida Sandra E.
Winter William J.
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