Ellipticine derivative and process for preparing the same

Details Ellipticine derivative and process for preparing the same Ellipticine derivative and process for preparing the same

1994-01-25

1996-10-15

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 31475

Patent

active

055655696

ABSTRACT:
An ellipticine derivative of the formula [I]: ##STR1## wherein R is a substituted lower alkyl group, a substituted or unsubstituted lower alkoxy group or a heteromonocyclic group,
or a pharmaceutically acceptable salt thereof, which show excellent antitumor activity, less side effects, less toxicity and/or high solubility in water and are useful as antitumor agent, and a process for preparing the same.

REFERENCES:
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patent: 4310667 (1982-01-01), LePeco et al.
patent: 4698423 (1987-10-01), Honda et al.
patent: 5272146 (1993-12-01), Haugwitz
patent: 5407940 (1995-04-01), Bisagni
patent: 5441941 (1995-08-01), Haugwitz
The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, Tenth Edition, p. 3511, (1983).
The Alkaloids Chemistry and Pharmacology, vol. XXV, p. 141, (1985).
Ratcliffe et al. Jour. Chem Soc Perkins I, (1988) pp. 2933-2943.

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