Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-29
2000-12-19
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 70, A61K 314745, C07D47104
Patent
active
061628115
ABSTRACT:
The compounds of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and A are as defined in the description, their optical isomers and N-oxides, and pharmaceutically acceptable addition salts thereof with an acid or base, and the use thereof as anti-tumor agents.
REFERENCES:
patent: 3933827 (1976-01-01), Brossi
patent: 5407940 (1995-04-01), Bisagni
patent: 5605904 (1997-02-01), Tsujihara
Tsujihara et al. in Chem. Pharm. Bull. 45(7) 1156-1162 (1997).
Atassi Ghanem
Bisagni Emile
Charton Yves
Guilbaud Nicolas
Guillonneau Claude
Adir et Compagnie
Huang Evelyn Mei
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