Ellipsoidal cell flow system

Details Ellipsoidal cell flow system Ellipsoidal cell flow system

1975-01-24

1976-03-23

Willis, Davis L.

Radiant energy

Luminophor irradiation

With ultraviolet source

356 39, G01N 2138

Patent

active

039462390

ABSTRACT:
The disclosure relates to a system incorporating an ellipsoidal flow chamber having light reflective walls for low level light detection in practicing cellular analysis. The system increases signal-to-noise ratio by a factor of ten over prior art systems. In operation, laser light passes through the primary focus of the ellipsoid. A controlled flow of cells simultaneously passes through this focus so that the laser light impinges on the cells and is modulated by the cells. The reflective walls of the ellipsoid reflect the cell-modulated light to the secondary focus of the ellipsoid. A tapered light guide at the secondary focus picks up a substantial portion of modulated reflective light and directs it onto a light detector to produce a signal. The signal is processed to obtain the intensity distribution of the modulated light and hence sought after characteristics of the cells. In addition, cells may be dyed so as to fluoresce in response to the laser light and their fluorescence may be processed as cell-modulated light above described. A light discriminating filter would be used to distinguish reflected modulated laser light from reflected fluorescent light.

REFERENCES:
patent: 3864571 (1975-02-01), Stillman et al.

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