Ellagic acid derivatives as phospholipase A.sub.2 inhibitors

Details Ellagic acid derivatives as phospholipase A.sub.2 inhibitors Ellagic acid derivatives as phospholipase A.sub.2 inhibitors

1990-07-16

1991-11-19

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3135

Patent

active

050666711

ABSTRACT:
There are disclosed a method for the treatment or prevention of immunoinflammatory conditions by administering to a mammal an effective amount of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each, independently, hydrogen, alkyl, aralkyl, aryl, or ##STR2## X is alkyl, aryl, or -NR.sup.5 R.sup.6 ; R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, or aryl; aryl is ##STR3## where the dotted line represents an optional double bond; R.sup.7, and R.sup.8 and R.sup.9 are each, independently, hydrogen, alkyl, hydroxy, alkoxy, carbalkoxy, halo, nitro, amino, cyano, trifluoromethyl, or a carboxylic acid;

REFERENCES:
patent: 3576007 (1971-04-01), Hochstein
patent: 3694557 (1972-09-01), Persinos
Beilstein, vol. 19, p. 285, 2d Ed.
Beilstein, vol. 19, p. 3164, 3/4 Ed.
Derwent Publications: 66-33545F.
Derwent Publications: 78-88538A.

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