Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1998-06-11
2000-04-11
Kunz, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
560 23, 560 30, C07C33700
Patent
active
060490063
ABSTRACT:
This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein: R.sup.1, R.sup.2, and R.sup.3 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.0-6 Ph where Ph is phenyl optionally substituted by halogen, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, C.sub.1 -C.sub.6 alkoxycarbonyl, --CO.sub.2 H or OH;
REFERENCES:
patent: 4983755 (1991-01-01), Buhmann et al.
Miller et al., Br. Med. J., 282:1741-1744 (1981).
Picardo et al., Arteriosclerosis., 6:434-441 (1986).
Glomset, J. Lipid Res., 9:155-167 (1968).
Glass et al., Circulation, vol. 66, Suppl. II 102 (1982).
MacKinnon et al., J. Biol. Chem., 261:2548-2552 (1986).
Grow and Fried, J. Biol. Chem., 253:8034-8041 (1978).
Lagocki and Scanu., J. Biol. Chem., 255:3701-3706 (1978).
Schaefer et al., J. Lipid Res. . , 23:1259-1273 (1982).
Tomita et al., J. Heterocyclic Chem., 27:707-710 (1990).
Vega and Grundy, Current Opinion in Lipidology, 7:209-216 (1996).
Russ et al., Am. J. Med., 11:480-493 (1951).
Gofman et al., Circulation, 34:679-697 (1966).
Miller and Miller, Lancet, 1:16-19 (1975).
Gordon et al., Circulation, 79:8-15 (1989).
Stampfer et al., N. England J. Med., 325:373-381 (1991).
Badimon et al., Lab. Invest., 60:455-461 (1989).
Christman Susan
Commons Thomas Joseph
American Home Products Corp.
Kunz Gary L.
Nagy Michael R.
White Everett
LandOfFree
Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydraz does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydraz, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydraz will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1177838