Elevation of HDL cholesterol by 2-(-4-chlorol-1-aryl-butylidene)

Details Elevation of HDL cholesterol by 2-(-4-chlorol-1-aryl-butylidene) Elevation of HDL cholesterol by 2-(-4-chlorol-1-aryl-butylidene)

1998-06-11

1999-12-28

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546305, 564 74, 549 77, 549 69, 549496, 549482, 514357, 514352, 514599, 514438, 514447, 514471, 514472, C07D21170, C07C32700, A61K 3138, A61K 3134, A61K 3144

Patent

active

06008362&

ABSTRACT:
This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are independently hydrogen, C.sub.1 -C.sub.10 alkyl, or --(CH.sub.2).sub.0-6 Ar.sup.1 where Ar.sup.1 is phenyl, furanyl, pyridinyl or thienyl, and Ar.sup.1 is optionally substituted by halogen, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, C.sub.1 -C.sub.6 alkoxycarbonyl, --CO.sub.2 H or OH; and Ar is phenyl, napthyl, furanyl, pyridinyl or thienyl optionally substituted by halogen, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, C.sub.1 -C.sub.6 alkoxycarbonyl, --CO.sub.2 H or OH.

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