Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1978-02-13
1979-03-13
Wolk, Morris O.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
1951035S, 23231, G01N 3114, G01N 3316, G01N 2106
Patent
active
041443063
ABSTRACT:
A multilayer analytical element for the analysis of liquids, particularly small samples of biological liquids, having at least two layers including a reagent layer and a registration layer. The reagent layer contains an interactive composition including a nondiffusible material having a preformed detectable moiety, such composition being interactive in the presence of liquid containing an analyte of choice to provide a diffusible product comprising the preformed detectable moiety. The registration layer receives the diffusible product released from the reagent layer. The layers present in the analytical element are composed such that the detectable moiety released from the reagent layer or that remaining unreleased in the reagent layer can be selectively detected in the element.
In one embodiment, there is disclosed an integral element which can include a support, preferably radiation-transmissive, on which a registration layer and a reagent layer are carried. Optionally, a spreading or analyte metering layer can be provided in the element adjacent the reagent layer to facilitate delivery of a uniform concentration of analyte to the reagent layer. In a preferred embodiment of this integral element, a radiation-blocking layer, permeable to the diffusible product, can be provided in the element intervening the reagent layer and the registration layer. The radiation-blocking layer, such as an opaque reflecting layer, can enhance the detection of the preformed detectable moiety in the registration layer or in the reagent layer by reflection densitometry or other appropriate radiometric technique.
The multilayer element of the invention is particularly useful, for example, in the assay of amylase as well as a variety of other analytes.
REFERENCES:
patent: 3641235 (1972-02-01), Weiss
patent: 3694318 (1972-09-01), Klein et al.
patent: 3888739 (1975-06-01), Whetzel et al.
patent: 3992158 (1976-11-01), Pygbylowicz et al.
patent: 4042335 (1977-08-01), Climent
Eastman Kodak Company
Hilst Ronald P.
Marcus Michael S.
Wolk Morris O.
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