Electrotransport device having improved cathodic electrode assem

Details Electrotransport device having improved cathodic electrode assem Electrotransport device having improved cathodic electrode assem

1994-04-08

1996-04-02

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

A61N 130

Patent

active

055036325

ABSTRACT:
An improved cathodic iontophoresis electrode assembly (8, 38) is provided having a reducible cathodic electrode (12,22) and a drug reservoir (14, 24) containing an anionic drug. The cathodic electrode (12, 22) is separated from the drug reservoir (14, 24) by means of a layer (30) of a cation exchange material. The cation exchange material is loaded with cations which are able to react with anions produced during reduction of the electrode (12, 22) to form an electrically neutral or substantially insoluble (eg, water insoluble) compound. The cathodic electrode (12, 22) is preferably composed of silver chloride which produces chloride ions during reduction. The cation exchange material is preferably loaded with silver or copper cations which react with the chloride ions to produce a neutral and relatively insoluble metal chloride salt.

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Ballestrasse, Cindy L. and Beck, Theodore R., "Acrylic Ion-Transfer Polymers", J. Electrochem. Soc.: Electrochemical Science and Technology, Nov., 1987, pp. 2745-2749, vol. 134, No. 11.

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