Electrostatic process for manufacturing coated transplants and p

Details Electrostatic process for manufacturing coated transplants and p Electrostatic process for manufacturing coated transplants and p

1995-04-14

1997-06-17

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424550, 424556, 424491, 536 3, A61K 914

Patent

active

056394675

ABSTRACT:
An electrostatic process for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gellable coating polymer solution in a continuous stream through an orifice. The stream is attenuated to form droplets by maintaining an electrostatic voltage between the needle and the gelling solution which is sufficient to maintain an attraction of at least 1.times.10.sup.6 newtons on the stream of liquid leaving the needle, and the droplets are collected in a gelling solution. A preferred product is pancreatic islets having a continuous, smooth coating of high polymannuronate non-fibrogenic alginate having a thickness of at least 10 .mu.m.

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